Association of increased interferon‐inducible gene ...

2006-8-31 · Association of IFN scores with anti-dsDNA antibody and hypocomplementemia in SLE patients. In these SLE patients, hypocomplementemia, anti-dsDNA antibody positivity, ongoing rash, and arthritis as well as renal involvement contributed to SELENA-SLEDAI scores. Hypocomplementemia was defined as serum levels of C3 or C4 below the normal range.

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Successful Treatment of Infectious Endocarditis …

2016-5-13 · hypocomplementemia.Thus,renalpathologyofdominant C3 deposition in our case was classified as postinfectious glomerulonephritis[6]. ... M. A. Ferreira et al., "Renal ... (Wegener''s granulomatosis) involving both the

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Pathology of the Cutaneous Vasculitides: A …

2018-9-25 · lesions (Grunwald et al., 1997). Detection of immunoreactants has the highest yield when taken from lesional rather than peri-lesional skin (Barnadas et al., 2004). Deposits of fibrinogen, C3 and IgM are most frequently present, but rarely IgG and C4 can also be seen (Grunwald et al., 1997).

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Peripheral Neuropathies in Systemic Lupus Erythematosus ...

Peripheral neuropathies cause severe pain, weakness, and psychosocial morbidity () the past decade, many studies of central nervous system (CNS) manifestations associated with systemic lupus erythematosus (SLE) have been conducted (2-5) ch studies have provided valuable insight into the spectrum of CNS manifestations and the association of distinct CNS …

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Henoch–Schönlein purpura with hypocomplementemia ...

2012-1-21 · Hypocomplementemia associated with HSP is a transient phenomenon. The incidence of significant sequelae such as HSPN between patients with and without hypocomplementemia does not differ. ... Low serum C3, leukopenia, and thrombocytopenia: unusual features of Henoch-Schonlein purpura.

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A boy with consecutive development of SLE and Wegener ...

2004-1-23 · An 11-year-old boy with consecutive development of systemic lupus erythematosus (SLE) and Wegener granulomatosis (WG) is presented. He was first admitted to the hospital with the findings of SLE, including crescentic glomerulonephritis, Coombs′ test-positive hemolytic anemia, hypocomplementemia, antinuclear antibody (ANA) positivity, and elevated levels of …

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A 26‐Year‐Old Woman With Asthma and Bilateral Ocular ...

In addition, hypocomplementemia of C3 and C4 is frequently present, particularly (but not exclusively) in patients with clinically evident IgG4‐related kidney disease, which usually presents as tubulo‐interstitial nephritis. ... (Wegener''s) (GPA) ... Her presentation was similar to that of patients described by Jacobiek et al in 1993 1, 4.

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IJMS | Free Full-Text | Complement Components C3 and C4 ...

Acute kidney injury (AKI) is a common and severe complication of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) causing progressive chronic kidney disease (CKD), end-stage renal disease (ESRD) or death. Pathogenic ANCAs, in particular proteinase 3 (PR3) and myeloperoxidase (MPO), trigger a deleterious immune response resulting in pauci …

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(PDF) C5a Receptor Mediates Neutrophil Activation and …

In multivariable analysis, C3 deposition was significantly associated with the composite end points after adjusting for age, sex, baseline eGFR, serum C3 level, treatment, and the percentage of ...

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Use of rituximab for granulomatosis with polyangiitis ...

2017-1-1 · A 31-year-old female patient, with a personal history of pulmonary tuberculosis 8 years ago with complete treatment, idiopathic diffuse bronchiectasis, giant cell tumor in the left proximal femur 9 years ago, cholecystectomy, without significant ocular personal antecedents.She consults for a clinical picture of 10 days of evolution, sudden onset, consisting of polyarthralgia, …

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Glomerular Disease in Two Patients With Urticaria ...

1981-11-1 · Glomerular Disease in Two Patients With Urticaria-Cutaneous Vasculitis and Hypocomplementemia. ... R Rent, EYC Choi, et al. Clq deficiency associated with urticarial-like lesions and cutaneous vasculitis. Am J Med, 61 (1976), pp. 560-565. ... (C3) and the hypocomplementemic cutaneous vasculitis syndrome. Am J Med, 68 ...

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Staphylococcus Infection-Associated Glomerulonephritis ...

Glomerular IgA and C3 (codominant) staining by direct immunofluorescence is commonly seen and is an important diagnostic feature. SAGN has often been termed "IgA-dominant" infection-associated GN ...

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Diagnostic value of serum complement C3 and C4 levels in ...

Hypocomplementemia was highly prevalent in patients with hematological disease (41.94 %). These results suggest that hypocomplementemia has important diagnostic value for SLE by improving the sensitivity of the diagnosis of SLE. C3 and C4 should be tested simultaneously because a low C3 or C4 level alone is not a suitable immunological criterion.

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Infective Endocarditis-Associated Purpura and ...

2021-7-31 · C3-dominant or codominant staining is the primary finding on immunofluorescence. 20 But IgA staining was found in 29% of cases with infective endocarditis-related glomerulonephritis, and IgA-dominant or codominant deposition was present in 17%. 20 Therefore, histologic overlaps exist between IgA vasculitis and infective endocarditis-related ...

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Predictors of renal and patient outcomes in anti ...

Hypocomplementemia. Overall, 68 of the 77 patients (88%) had C3 and C4 complement levels measured at admission. Mean serum C3 level was 118.7±39.8 mg/dL and was significantly lower in the patients with renal involvement (114.6±37.9 mg/dL), compared to those without renal involvement (138.3±44.7 mg/dL) (p=0.042).

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Complement analysis in children with idiopathic ...

2001-6-1 · Fifty children with idiopathic membranoproliferative glomerulonephritis (MPGN), aged 2–14 years at apparent onset, were monitored for the presence of C3 nephritic factor (C3 NeF) and signs of complement activation in serum. In addition, C3 allotyping was performed in 32 patients. Observation time ranged from 2 to 20 (median 11) years. C3 NeF activity was …

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Wegener''s granulomatosis: causes, symptoms, diagnosis, trea…

Wegener''s Granulomatosis Etanercept Trial Research Group [26]. ESRD was defined as the onset of chronic dialysis or renal transplantation. PR3- and MPO-ANCA were determined by ELISA. C3 and C4 levels were assessed by nephelometry (Behring BNII nephelometer). Only GPA and MPA patients with available C3 and C4 plasma levels that were obtained ...

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Endocarditis associated with antineutrophil cytoplasmic ...

2006-1-27 · Grant SC, Levy RD, Venning MC et al (1994) Wegener''s granulomatosis and the heart. Br Heart J 71(1):82–86. PubMed CAS Google Scholar 29. Hafezi-Rachti S, Riess R, Weidner S et al (2000) The patient with Wegener''s granulomatosis and an intrasplenic mass of unknown origin. Nephrol Dial Transplant 15(6):906–908

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Hypocomplementemia is associated with worse renal …

2018-4-5 · Hypocomplementemia with low C3 and/or C4 levels at GPA or MPA diagnosis may be responsible for worse survival and renal prognosis. These results argue for larger and prospective studies to better determine the epidemiology of the disease and to assess complement-targeting therapy in these patients.

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New clues to the nature of immunoglobulin G4-related ...

2017-12-1 · Patients with low C3 and C4 defined as C3 < 86 mg/dl and C4 < 17 mg/dl were seen in 34.7% and 33.7%, respectively. The frequency of low C3 in patients with kidney lesion was significantly higher than in those without (55.4% vs 27.8%, p < 0.000) (Table 4).

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A primer on recurrent and de novo glomerulonephritis in ...

2008-6-17 · Briganti EM et al. (2002) Risk of renal allograft loss from recurrent glomerulonephritis. N Engl J Med 347: 103–109. Article Google Scholar 11. Nankivell BJ et al. (2004) Evolution and ...

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Diagnostic Testing and Interpretation of Tests for ...

2021-11-15 · Hypocomplementemia is generally not specific for any disease and may be secondary to nonrheumatic diseases such as subacute bacterial endocarditis or poststreptococal glomerulonephritis. If C4 is low compared to C3, it may indicate the presence of cryoglobulins or the genotype C4 null allele.

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Henoch–Schönlein purpura with hypocomplementemia ...

2012-1-21 · Henoch–Schönlein purpura (HSP) is a common form of systemic vasculitis in children, and the complement system is believed to play a role in its pathogenesis, despite the fact that serum levels of complement 3 (C3) and complement 4 (C4) are within the normal range for most patients [1–4].Abnormalities of the complement system in HSP have been previously …

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An Approach to the Child with Acute Glomerulonephritis

2011-11-24 · Acute glomerulonephritis (AGN) is a common condition in childhood. Many children with AGN can be managed in the primary care setting. The diagnosis is usually made on the basis of urinary findings, especially the presence of red blood cell casts. One of the most important initial investigations is determining the complement C3 level; hypocomplementemia is most …

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The etiology of glomerulonephritis: roles of infection and ...

2014-11-1 · Nearly 200 years ago, Richard Bright first described glomerular disease, diagnosing proteinuria in his patients by using a candle to heat urine on a spoon to determine whether it precipitated with heat. 1 Bright also first recognized the relationship of scarlatina (due to streptococcal infection) to subsequent glomerulonephritis (GN) in the 1800s. . With the advent …

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Complement Components C3 and C4 Indicate Vasculitis ...

2021-6-19 · 2.2. Hypocomplementemia Is Detectable in a Minor Subset of ANCA GN and Not Correlated with Renal or Extrarenal AAV Manifestations. We first analyzed frequency of hypocomplementemia at disease onset of AAV and separated groups for decreased C3c (<0.82 g/L, normal range: 0.82–1.93 g/L) and C4 levels (<0.15 g/L, normal range: 0.15–0.57 g/L).

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Review article: Pathogenic role of complement activation ...

2009-3-31 · Venge and Olsson 91 and Johnson et al. 92 demonstrated that proteases derived from human PMN are able to convert C3 and/or C5. Recently, Xiao et al. 87 showed that the activation of human neutrophils by human MPO-ANCA or Pr3-ANCA IgG releases factors that activate complement with the generation of C3a. Although this study does not identify what ...

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Necrotizing ANCA-Positive Glomerulonephritis Secondary …

Hypocomplementemia (low C3 and/or C4 levels) was found in 56% of patients tested and ANCA antibodies in as many as 28%, with mostly anti-PR3 specificity, although anti-MPO and dual-positive anti-PR3 and anti-MPO were also seen. ... G. S. Hoffman, G. S. Kerr, R. Y. Leavitt et al., "Wegener granulomatosis: an analysis of 158 patients," Annals ...

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ANCA associated vasculitis: The Journey to complement ...

2021-8-26 · In 2015, Manenti et al. reported, in a study that included 46 patients with AAV, that 35% of these individuals had decreased levels of C3 in serum, and this finding was associated with decreased renal survival and the presence of renal thrombotic microangiopathy in …

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A boy with consecutive development of SLE and Wegener ...

An 11-year-old boy with consecutive development of systemic lupus erythematosus (SLE) and Wegener granulomatosis (WG) is presented. He was …

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